If California and Massachusetts were their own independent nations, they would be near the top of the list of major medtech headquarters countries worldwide.
Of the 100 companies in this year’s Medtech Big 100 report, 17 were based in California — more than the 14 in Japan. Massachusetts’s six matched Germany.
It was one of many data points showing the Golden State and Bay State’s medical device strength. (Minnesota, the other major U.S. medtech hub, has large industry presences but only two major headquarters — or three if you count the largest medtech company in the world, Medtronic, which is officially based in Ireland for tax purposes but is run operationally out of Fridley, Minnesota.)
Below is a map of major medtech headquarters worldwide. (For more details, go to our sibling Medical Design & Outsourcing site for a free download of our 2026 Medtech Big 100 Special Report.)
