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Home » The 10 largest orthopedic device companies in the world

The 10 largest orthopedic device companies in the world

May 12, 2026 By Chris Newmarker

This is an image of Mako robotic orthopedic surgery systems which have fuled growth at the world's largest orthopedic device company.
Stryker’s orthopedics business continues to enjoy strong growth on the success of its Mako family of robotic orthopedic surgery sytems. [Image courtesy of Stryker]
The world’s 10 largest orthopedic device companies grew their combined revenue by more than 5% over the past year, bringing in more than $46 billion as innovations, including orthopedic surgical robotics, drive growth.

In fact, the success of Stryker’s Mako line of robots and the resulting sales of complementary implant systems enabled it to surpass Johnson & Johnson’s DePuy Synthes as the largest orthopedic device business in the world. Stryker was able to make the leap even in the wake of selling its spinal implants business to Viscogliosi Brothers, creating the new privately-held VB Spine.

Download our free MassDevice Orthopedic Device Companies Special Report for detailed listings about the top 10 companies and feature stories that explore some of the space’s most innovative technologies.

Here’s a peek at how the top 10 list turned out:

Here is a list of the 10 largest orthpedic device companies in the world with annual revenue for the 10 companies blurred.

Download our free report on the world’s largest orthopedic device companies>>

And here’s last year’s rankings>>

And here’s our 2024 rankings>>

Filed Under: Business/Financial News, Featured, In-Depth Coverage, Metal-on-Metal, Orthopedic Implants, Orthopedics, Special Content, Spine, Surgical Robotics Tagged With: Alphatec, Arthrex Inc., Atec, DePuy Synthes, Enovis, Globus Medical, Johnson & Johnson, Johnson & Johnson MedTech, Medtronic, Orthofix, Smith+Nephew, Stryker, Zimmer Biomet

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About Chris Newmarker

Chris Newmarker is the executive editor of WTWH Media life science's news websites and publications including MassDevice, Medical Design & Outsourcing and more. A professional journalist of 18 years, he is a veteran of UBM (now Informa) and The Associated Press whose career has taken him from Ohio to Virginia, New Jersey and, most recently, Minnesota. He’s covered a wide variety of subjects, but his focus over the past decade has been business and technology. He holds bachelor’s degrees in journalism and political science from Ohio State University. Connect with him on LinkedIn or email at [email protected].

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