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Home » FDA Commissioner Marty Makary resigns; Trump names acting replacement

FDA Commissioner Marty Makary resigns; Trump names acting replacement

May 12, 2026 By Skyler Rivera

A photo of former FDA Commissioner Marty Makary
Former FDA Commissioner Marty Makary [Photo courtesy of the FDA]
Dr. Marty Makary resigned as commissioner of the FDA on Tuesday, with President Donald Trump saying FDA Deputy Commissioner for Food Kyle Diamantas will lead the agency as acting commissioner.

Before joining the agency, Diamantas was a Jones Day lawyer who represented Abbott in a lawsuit in which the company was ordered to pay $495 million, according to the New York Times. The Times said the lawsuit accused Abbot of failing to  “adequately warn parents that its specialized formula for premature infants was associated with an elevated risk of a deadly bowel condition.”

Trump posted an image of a text message from Makary offering his immediate resignation on social media.

“He’s going to go on and he’s going to lead a good life,” Trump said. “He was having some difficulty. … Everybody wants that job.”

Previously: Mass layoffs start at HHS: ‘FDA as we’ve known it is finished’

Makary’s resignation comes after weeks of increasing pressure from the Trump administration and Trump himself demanding that Makary authorize the sale of fruit-flavored e-cigarettes, according to the New York Times.

Citing anonymous sources, the publication said Makary ultimately left over concerns about the Trump administration’s decision to authorize flavored vapes, an action that he opposed. Makary reportedly told those close to him that “he could not in good conscience approve flavored vapes, given their appeal to young people, and would not do something he did not believe in.”

Politico said an anonymous senior administration official told it the Trump administration’s decision to move on from Makary was months in the making. While the White House had to sign off on the plan to fire Makary, Politico’s source said that HHS Secretary Robert F. Kennedy Jr. ultimately made the call.

Related: FDA pilots program for more facility inspections

Filed Under: Featured, Food & Drug Administration (FDA), Regulatory/Compliance Tagged With: FDA, leadership, U.S. Department of Health and Human Services

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About Skyler Rivera

Skyler Rivera is an associate editor at Arrowfly, covering medical device industry news and technology at MassDevice and Medical Design & Outsourcing. She began her career covering sports at The Athletic and MLB before transitioning to medical writing at Edwards Lifesciences. Based in Southern California, she holds a master's degree in science writing from Johns Hopkins University and a bachelor’s in broadcast journalism from Syracuse University. Connect with her on LinkedIn or email at [email protected].

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