The Medical Device Plug-and-Play (MD PnP) Interoperability program at CIMIT / Massachusetts General Hospital has been leading the clinical pull for adoption of medical device interoperability for more than five years. We are a multi-institutional, interdisciplinary collaborative program of stakeholders (including medical device companies and regulatory agencies as well as healthcare delivery organizations) who want to see open standards and technology for interoperability developed and adopted, based on clinical requirements.