Researchers at the Mayo Clinic‘s tissue engineering and biomaterials laboratory have developed a 3D-printed, porous scaffold for the delayed delivery of recombinant-human bone morphogenetic protein 2, rhBMP-2, to facilitate bone regeneration in patients undergoing ACL reconstruction. The team’s work developing the scaffold and comparing different delivery methods for rhBMP-2 was published this week in Tissue Engineering. […]
Research & Development
Clearside bails on AMD, all-in on diabetic macular edema
Clearside Biomedical (NSDQ:CLSD) said today it will redirect its R&D efforts from its pre-clinical axitinib wet age-related macular degeneration therapy to its Zuprata diabetic macular edema treatment. The Alpharetta, Ga.-based company said that recent trial results from other companies investigating combination therapies for wet AMD have led Clearside to reconsider its proprietary suspension formulation of […]
Study: Nanotechnology could cut dose of HIV treatment in half
Researchers from the University of Liverpool presented data this week evaluating the use of nanotechnology to improve drug therapies for HIV patients. The team touted its data at the Conference on Retroviruses and Opportunistic Infections in Seattle. The trial enrolled healthy patients and evaluated the use of orally-dosed solid drug nanoparticles to optimize HIV therapy, according […]
Children’s National Health System highlights novel approach for cell therapy
Children’s National Health System touted data today from a Phase I dose-ranging study evaluating a cell therapy approach in patients with blood and bone marrow cancers for whom stem cell transplantation hasn’t worked. Results from the Resolve trial showed that 78% of patients responded to multi-tumor-associated antigen specific lymphocytes (TAA-L) treatment and 44% of patients […]
‘Electronic tattoos’: Could they be the future of wearables?
Japanese researchers have pushed the boundaries even further when it comes to flexible electronics for wearable medical devices. They say they used a household inkjet printer without soldering to produce 750 nm–thin elastomeric sheets that feel like an “electronic tattoo” The result of the Waseda University researchers’ work was ultrathin stick-on electronic devices using elastomeric “nanosheet” […]
These nanostraws can sample cells without damaging them
Stanford University researchers say they’ve developed nanostraws capable of sampling cell contents—all without disrupting natural processes. The innovation has the potential to provide non-destructive cell monitoring versus lysing, the cell sampling method presently used. Lysing ruptures the cell, while the sampling method developed at Stanford relies on tiny tubes that are 600 times smaller than […]
Researchers develop smart drugs using ‘DNA computers’ for controlled delivery
Researchers from the Eindhoven University of Technology have developed the 1st “DNA computer” that can detect several antibodies in the blood and perform calculations based on what it detects. The team published their work in Nature Communications and said that it’s an important step towards developing smart drugs that allow for more targeted and controlled medication delivery. […]
Genetically engineered T-cells treat leukemia in babies
Researchers in London have successfully treated leukemia in two babies, in what they are touting as the world’s first treatment of cancer using genetically engineered immune cells from donors. Two British infants, who were 11 and 16 months old, were treated using Cellectis’ CAR T-cell product, UCART19, which is an allogeneic CAR T-cell product candidate […]
How virtual and mixed reality are changing drug delivery and device design
Kai Worrell believes that virtual and mixed reality may change the way companies design medical devices, and he’s putting that idea into practice. “We think it’s going to transform the way we do feasibility testing and cognitive walk-through simulations,” he said. “We think it’s going to help us understand the cognition of our users, clinical […]
Insulet touts Omnipod Horizon hybrid closed-loop system in patients with T1D
Insulet (NSDQ:PODD) touted data today from the 1st feasibility study of its Omnipod Horizon hybrid closed-loop system in patients with Type 1 diabetes. Data from the study showed that the Omnipod automated glucose control algorithm performed well, with minimal hypoglycemia, and that it was safe. The Billerica, Mass.-based company enrolled 24 patients with Type 1 diabetes […]
Virus shells target and deliver drugs to cancer cells
Researchers from Australia and the UK have developed virus-like nanoparticles to target and deliver drugs to cancer cells. The team’s work, which was published in the journal ACS Nano, showed that the particle could be produced in plants and that it can shuttle small molecules to cancer cells for targeted treatment. The team, lead by Frank […]