Sensor-driven disease detection company Glympse Bio has raised $22 million in a Series A round to fund clinical trials for its technology. The Cambridge, Mass.-based company uses bioengineered activity sensors transported to the site of disease in patients to investigate biological targets such as proteases – a class of enzymes that drive critical disease pathways. Once a disease […]
Researchers use microparticles for targeted delivery of brain cancer therapy
A team of researchers from Brigham & Women’s Hospital, Mass. Institute of Technology and Mass. General Hospital demonstrated that localizing the delivery of NAMPT inhibitors can extend survival in a mouse model of glioma, according to a paper published this week in the Proceedings of the National Academy of Sciences. The scientists created a test to check for a mutation linked […]
Acorda’s CEO on failure, perseverance and the profound risks of drug development
Dr. Ron Cohen isn’t easily deterred. The physician-turned-executive has spent decades in the biotech industry and weathered a number of setbacks – he learned in his early years at the now-defunct Advanced Tissue Sciences that to succeed, he needed resilience. “I learned that it took hundreds of millions of dollars if not billions to develop […]
Researchers deliver cardiac stem cell therapy in preclinical trial using refillable patch
Researchers have developed a small device designed to halt the effects of a heart attack by delivering a stem cell therapy directly to damaged cardiac tissue. In a study published in Nature Biomedical Engineering, researchers from Harvard University, the Massachusetts Institute of Technology, the National University of Ireland Galway and Trinity College Dublin reported that the […]
MIT researchers send drug-ferrying nanoparticles across the blood-brain barrier
Researchers at the Massachusetts Institute of Technology demonstrated in an animal study that nanoparticles shuttling two different cancer drugs could effectively cross the blood-brain barrier and target tumor cells. The team of scientists evaluated the drug combination in mice that had gliobastoma – an aggressive form of brain cancer that is notoriously hard to treat. […]
MIT researchers devise single-injection delivery method for polio vaccine
Although most of the world is protected from the polio virus thanks to a vaccine developed decades ago, some countries remain vulnerable to the disease thanks to challenges posed by a vaccine that requires repeat dosing. Researchers from the Massachusetts Institute of Technology want to change that with a nanoparticle vaccine that can deliver multiple doses of […]
This fluorescent dye could create clearer biological imaging
Massachusetts researchers have repurposed a commercially-available dye that has been around since the 1950s to make short-wave infrared easily available for clearer imaging. Fluorescence imaging is often used to visualize biological tissues or blood vessels during reconstructive surgery to see if vessels are connected properly. Currently, researchers use a dye that runs at the near-infrared […]
MIT study reveals the problem with bioresorbable stents
Bioresorbable coronary scaffolds, designed to avoid the risks associated with the long-term implantation of metal stents, once captured the attention of medtech giants like Abbott (NYSE:ABT) and Boston Scientific (NYSE:BSX). But companies have since linked the use of these biodegradable polymer-based devices to a heightened risk of myocardial infarction and thrombosis, prompting Abbott to pull its Absorb product from the […]
Drug delivering contact lenses win MIT’s top healthcare innovation prize
Contact lenses that deliver medications directly to the eye over a period of days or weeks was the recent grand prize winner of Massachusetts Institute of Technology’s Sloan Healthcare Innovation Prize. The MIT Sloan Healthcare Innovation Prize competition had 8 finalists who pitched their healthcare innovations to judges from Optum and other local venture firms, […]
Researchers develop capsule to deliver a week’s worth of HIV drugs
A team of researchers from the Massachusetts Institute of Technology and Brigham & Women’s Hospital have developed a drug-delivery capsule that can deliver a week’s worth of HIV drugs in a single dose. The technology is designed to make it easier for people with HIV to deal with the strict schedule of medications they need to take to […]
Philips to move North America HQ to biotech hotspot Cambridge
Royal Philips (NYSE:PHG) plans to move its North American headquarters and nearly 2,000 employees to Cambridge, Mass. in 2020, according to reports. The medical technology company partners with a number of Cambridge- and Boston-based hospitals and institutions, so its decision to move to the Cambridge Crossing campus was one, partially, of convenience. “It just made sense […]
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