Campbell, California-based Imperative Care designed the Zoom solution to treat those with acute ischemic stroke. It features the Zoom 88 large distal platform for neurovascular access, four-vessel-matched Zoom aspiration catheters, the Zoom Pump, Zoom POD and other accessories.
The company presented data from studies evaluating Zoom at the Society of NeuroInterventional Surgery (SNIS) 2022 19th Annual Meeting in Toronto.
“At Imperative Care, we know that clinical data are foundational to validating medical technologies and improving patient outcomes,” Daniel Davis, president and COO of Imperative Care, said in a news release. “The results from these studies are a meaningful step forward in ongoing efforts to collect real-world evidence on the safety and efficacy of our technologies, and we look forward to continuing our clinical progress in collaboration with the neurointerventional community.”
Results from an independent, single center experience evaluating the association between guide catheter position and final reperfusion in patients who received aspiration thrombectomy for ischemic stroke were presented by Dr. James Milburn, of Ochsner Health, New Orleans.
Findings demonstrated that intracranial guide catheter placement in the petrous internal carotid artery (ICA) segment or further distal versus placement in the cervical ICA segment or more proximal was associated with a better rate of TICI≥2C reperfusion (82.7% compared to 60%, respectively).
Additionally, the study demonstrated a better first-pass effect — 51% compared to 27.5% — while access time to final recanalization was significantly shorter in patients with intracranial guide catheter placement (23.8 minutes) compared to those with proximal guide catheter placement (33.9 minutes).
“The introduction of large bore guide catheters that can track further in the brain has been a game-changer for the treatment of ischemic stroke,” Milburn said. “These results further support that intracranial access is directly associated with improved reperfusion, or as evidenced by this study, final TICI 2C or better reperfusion rate.
“The Zoom 88 Large Distal Platform has become my default guide catheter for stroke. Going further up into brain and closer to the clot with Zoom 88 results in enhanced navigation support and improves first pass effect by losing clot less frequently and achieving quicker access in patients suffering emergent large vessel occlusions.”
A study evaluating the effect of intracranial flow parameters using various guide catheters for aspiration thrombectomy had its results presented by Holly Berns, Ph.D. candidate, Northern Arizona University.
The study showed a 67% flow reduction in the middle cerebral arterial (MCA) when a Zoom 88 access catheter was positioned distal to the posterior communicating artery and proximal to the carotid terminus. The flow reduction was significantly greater when compared to the 54% reduction achieved with an inflated balloon guide catheter positioned in the proximal ICA.
Comparatively, the study demonstrated that placing a long sheath in the proximal ICA resulted in approximately 30% flow reduction in the MCA, or less than half the flow reduction achieved with Zoom 88 at the carotid terminus.
“Significantly reduced flow locally at the thrombus location can meaningfully reduce potential downstream migration during mechanical thrombectomy,” said senior author of the study, Timothy A. Becker of Northern Arizona University. “The findings from this study demonstrate that distal placement of a Zoom 88 can translate to better flow reduction than a balloon guide catheter without substantial reduction to collateral or ipsilateral flow and the additional time required to set up the balloon placed proximally.”
Milburn presented another single-center report on the Zoom solution that evaluated an aspiration-first approach using Zoom catheters in patients with ICA, M1 and M2 occlusions. The study found that the use of angled-tip aspiration catheters for thrombectomy was associated with quicker time to final reperfusion, lower use of stent retrievers and lower use of additional aspiration catheters, suggesting a reduction in the cost of the procedure.