Our Weekly Checkup takes the temperature of the medical device industry’s three largest U.S. clusters: Massachusetts, California and Minnesota.

The MassDevice Indices are weighted according to market capitalization, based on the number of shares outstanding for each company and each Friday’s closing share price.

The Massachusetts index for the week ended June 17 closed at 6.11, up 0.7 percent compared with the prior week. Since Jan. 1, 2009, when we began tracking these companies, the index has risen 38.0 percent.

The Minnesota index for the week ended June 17 closed at 4.12, down 0.7 percent compared with the prior week. Since Jan. 1, 2009, when we began tracking these companies, the index has risen 39.8 percent.

The California index for the week ended June 17 closed at 9.93, up 1.0 percent compared with the prior week. 134.1 Jan. 1, 2009, when we began tracking these companies, the index has risen YY percent.

We also create a composite index of the three regional indices and compare it with four other indices (the S&P 500, the Dow Jones Industrial Average, the Dow’s IHI medical devices index and the NASDAQ exchange):

The Weekly Checkup also compares Monday morning’s opening share prices with their value when the markets close Friday afternoon to calculate the biggest gainers and losers.

Here are the 20 firms that posted the biggest share price gains and losses during the week ended June 17:

The 10 biggest gainers:

1. Biopure Corp.: 14.29% (open $0.01; close $0.01)
2. Cambridge Heart Inc.: 11.76% (open $0.17; close $0.19)
3. World Heart Inc. : 8.68% (open $0.92; close $1.00)
4. NeuroMetrix Inc.: 7.37% (open $0.47; close $0.51)
5. Interleukin Genetics Inc.: 5.26% (open $0.38; close $0.40)
6. Harvard Bioscience Inc.: 3.62% (open $4.97; close $5.15)
7. Hansen Medical Inc. : 3.28% (open $2.74; close $2.83)
8. Vision-Sciences Inc. : 3.27% (open $2.45; close $2.53)
9. Biolase Technology Inc. : 2.98% (open $5.70; close $5.87)
10. Digirad Corp. : 2.85% (open $2.46; close $2.53)

Sources: Google Finance and Yahoo! Finance.

And the 10 biggest losers:

1. Vascular Solutions Inc. : -7.08% (open $12.71; close $11.81)
2. Staar Surgical Company : -5.71% (open $5.43; close $5.12)
3. Conceptus Inc. : -4.61% (open $12.15; close $11.59)
4. Cynosure Inc.: -4.32% (open $11.58; close $11.08)
5. American Superconductor Corp.: -4.19% (open $7.88; close $7.55)
6. HepaLife Technologies: -3.96% (open $0.10; close $0.10)
7. Alphatec Holdings Inc. : -3.68% (open $3.53; close $3.40)
8. Cutera Inc. : -3.53% (open $7.94; close $7.66)
9. American Shared Hospital Services : -3.32% (open $3.31; close $3.20)
10. icad Inc.: -2.86% (open $1.05; close $1.02)

Sources: Google Finance and Yahoo! Finance.

Disclaimer: MassDevice.com’s rankings do not reflect an opinion of companies’ health, prospects or viability. They are intended to provide a snapshot of publicly traded medical device companies and in no way constitute a recommendation to buy or sell any particular security, portfolio of securities, transaction or investment strategy.