Researchers at the University of Illinois and the Agency for Science, Technology & Research in Singapore are using the gene-editing tool CRISPR-Cas9 to uncover potentially useful drug compounds.
The team has used CRISPR-Cas9 to turn on “silent” gene clusters in Streptomyces and express genes that naturally produce drug compounds to be used as antibiotics or anti-cancer agents. Their work was published in Nature Chemical Biology.
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